Sepsis
Conditions
Keywords
sepsis, miRNA
Brief summary
Sepsis is a common cause of death in intensive care unit, timely and accurate diagnosis and treatment directly affect the survival rate. MiRNA is a post-transcriptional small RNA which regulate mRNA expression. The present study was designed to screen several miRNA by microarray which evaluate the sepsis prognosis in order to be a new target for the treatment of sepsis.
Detailed description
The study is a non-intervention, prospective observational study. Purpose of this sudy is to screening several miRNAs by microarray which can evaluate the prognosis of sepsis . We will collect serum samples from patients with sepsis in SICU, RICU and EICU of 301 Hospital since September 2009 , and then use the chip and qRT-PCR to Screen miRNAs which can evaluate the prognosis of sepsis, and statistical analysis the miRNAS expression correlation with SOFA score.
Interventions
None listed
Sponsors
Chinese PLA General Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Clinical diagnosis of sepsis * Patients who agree with the study
Exclusion criteria
* Aged \<18 years; * Into the group who died within 24 hours; * Agranulocytosis (\<0.5 × 109 / L); * Combined HIV infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| all cause mortality | 28days after admited in ICU |
Countries
China
Contacts
Primary ContactHuijuan Wang, master
Outcome results
None listed