Atherosclerosis, Cardiovascular Diseases, Coronary Artery Disease, Coronary Disease, Heart Diseases
Conditions
Brief summary
South Asian (Indian, Pakistani, Bangladeshi, Nepali, and Sri Lankan) individuals have high rates of cardiovascular disease that is not explained by traditional cardiovascular risk factors. Though South Asians represent over one-quarter of the world's population, there are no longitudinal studies in this high-risk ethnic group. The investigators aim to establish a longitudinal study of South Asians at three United States centers to identify risk factors linked to subclinical atherosclerosis and incident cardiovascular disease. The purpose of this study is to understand the causes of heart disease and stroke in South Asians and compare these causes to those in other United States ethnic groups.
Interventions
None listed
Sponsors
University of California, San Francisco
Northwestern University
National Heart, Lung, and Blood Institute (NHLBI)
National Institute on Minority Health and Health Disparities (NIMHD)
New York University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to 84 Years
Healthy volunteers
No
Inclusion criteria
* South Asian ancestry defined by having at least 3 grandparents born in one of the following countries: India, Pakistan, Bangladesh, Nepal, or Sri Lanka * age between 40 and 84 years.
Exclusion criteria
* Physician diagnosed heart attack, stroke or transient ischemic attack (TIA), heart failure, or angina (or use of nitroglycerin) * Current atrial fibrillation * Past history of cardiovascular procedures (coronary artery bypass graft (CABG) Surgery, angioplasty, valve replacement, pacemaker or defibrillator implantation, or any surgery on the heart or arteries) * Active treatment for cancer * Life expectancy less than 5 years due to serious medical illness * Impaired cognitive ability as judged by the reviewer * Plans to move out of the study region in next 5 years * Weight greater than 300 pounds * Living in a nursing home or on a waiting list * Unable to speak/read/write English, Hindi, Urdu, or Bangla
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coronary artery calcium prevalence in South Asians | Baseline |
Secondary
| Measure | Time frame |
|---|---|
| Change from baseline Coronary artery calcium prevalence in South Asians at 4 years | Baseline to Year 4 |
| Incidence of type 2 diabetes after approximately 4 years of follow-up | Baseline to Year 4 |
| Carotid intima media thickness | Baseline |
| Diabetes Prevalence | Baseline |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORAlka Kanaya, MD
University of California, San Francisco
PRINCIPAL_INVESTIGATORNamratha Kandula, MD
Northwestern University
PRINCIPAL_INVESTIGATORNadia Islam, PhD
New York University
Outcome results
None listed