Bariatric Surgery Candidate
Conditions
Keywords
knee arthrosis, obesity, MRI, bariatric surgery
Brief summary
Impact of loss of weight on knee arthrosis has not been thoroughly studied. The primary goal of this study is to compare the MRI parameters (aspect of cartilage and oedema of spongious sub-chondral bone) before and one year after bariatric surgery. Knee MRI is not currently part of the investigations preceding bariatric surgery.
Detailed description
Assessment of knee arthrosis in severely obese patients after bariatric surgery. Impact of loss of weight on knee arthrosis has not been thoroughly studied. The primary goal of this study is to compare the MRI parameters (aspect of cartilage and oedema of spongious sub-chondral bone) before and one year after bariatric surgery.
Interventions
OTHERknee MRI
knee MRI before surgery (inclusion) and one year after
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 59 Years
Healthy volunteers
No
Inclusion criteria
* bariatric surgery * IMC \>= 35
Exclusion criteria
* those of bariatric surgery * contra-indication to MRI * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| variation of knee joint space thickness | 24 hours, one year | Joint space variation in percentages (mean joint space variation calculated for each patient group). Mean joint space comparison between 2 groups of obese patients: patients with Bypass surgery versus patients without surgery. |
| proportion of patients with pain | 1 year | proportion of patients with Pain Scores on the Visual Analog Scale ≥ 30/100 (for at least one knee). Comparison at one year after bariatric surgery versus inclusion. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| evolution of KOOS score after surgery | 6 months, 1 year and two years | Among the 80 patients undergoing surgery, comparison of KOOS function score before surgery versus 6 months, 1 year and two years after surgery. |
| evolution of pain scores after surgery | 6 months, 1 year, 2 years | Among the 80 patients undergoing surgery, comparison of mean Pain Scores on the Visual Analog Scale before surgery versus 6 months, 1 year and two years after surgery. |
| prevalence of atherosis | 24 hours | Pain Scores on the Visual Analog Scale \>= 3 and/or radiological signs of atherosis |
| evolution of knee MRI parameters after surgery | 6 months, 1 year and two years | Among the 80 patients undergoing surgery, comparison of the MRI parameters (T2, cartilage volume, œdema of sub-chondral spongious bone) before surgery versus 6 months, 1 year and two years after surgery. |
| evolution of the proportion of patients in pain | 6 months, 1 year and two years | Among the 80 patients undergoing surgery, comparison of the proportion of patients with Pain Scores on the Visual Analog Scale ≥ 30/100 before surgery versus 6 months, 1 year and two years after surgery. |
| mean pain and disability | 24 hours | mean Pain Scores on the Visual Analog Scale and mean value of KOOS index for knee function. |
Countries
France
Outcome results
None listed