Craniopharyngioma
Conditions
Keywords
Craniopharyngioma, Surgery, Intraoperative imaging, Rate of total removal
Brief summary
Purpose of this study is to investigate whether intraoperative imaging using a 1.5T MRI in craniopharyngioma surgery is useful in order to increase the rate of complete tumor removal.
Interventions
OTHERIntraoperative imaging using 1.5T MRI
Intraoperative imaging and determination of degree of resection / complete tumor removal
Sponsors
Hofmann, Bernd, M.D.
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
3 Years to 75 Years
Inclusion criteria
* complex craniopharyngioma \> 1cm extension within 2 or more cranial fossae or ventricular system * Patient or legal representative able to provide written informed consent
Exclusion criteria
* tumor size\< 1 cm * Patients with any condition considered a contraindication to MRI * Patients with any condition considered a contraindication for surgery * Hypothalamic disturbances * Hypothalamic edema
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of additional tumor removal | up to 3-4 months following surgery | Number of patients in whom non suspected tumor remants were indicated by intraoperative MRI and remnants could be removed completely thereafter. Results have to be confirmed in 1st follow up imaging. |
| Rate of achievement of intended extent of removal | up to three months following surgery | It is examined whether the extent of tumor removal defined prior to surgery was achieved |
| Diagnostic reliability | within 3 -4 months following surgery | false positive or negative interpretation of intraoperative imaging determined after follow-up imaging 3 - 4 months following surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Surgical complication | within 1st week following surgery | Rate of new deficits following surgery (excluding new endocrine deficits) |
Countries
Germany
Outcome results
None listed