Chronic Obstructive Pulmonary Disease, Lung Transplantation
Conditions
Keywords
Confocal Laser Scanning Microendoscopy, Small airways, COPD, Lung transplantation
Brief summary
Aspects of confocal laser micro-endoscopy (CLME) and morphometry in chronic obstructive pulmonary disease (COPD) and lung transplant recipients is described and will be correlated with clinical findings in order to described small airway remodelling in these patients.
Detailed description
In early phases of COPD, changes in small airway characteristics may develop. Elastin decay and matrix remodelling could be responsible for these changes. Using CLME changes of in the bronchiolar wall and alveolar ducts can be visualized, described and measured. In lung transplant recipients, CMLE will be performed to distinguish characteristics of distal airways in stabile patient in contrast to patients with bronchiolitis obliterans syndrome. In both groups data will be correlated with CT findings, pulmonary function tests and anatomopathological results.
Interventions
None listed
Sponsors
KU Leuven
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* referral for bronchoscopic investigation/sampling * informed consent signed * recent spirometric data
Exclusion criteria
* sedated and/or ventilated patients * patients on ICU * patients under oral anticoagulation * co-existing lung disease * acute infectious pulmonary disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| morphometry | 90 - 180 - 360 - 540 - 720 days | morpohometrical analysis at different time point after lung transplantation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| adverse events | 90 - 180 - 360- 540- 720 days | bleeding, pneumothorax, pleuritic chest pain during procedure |
Countries
Belgium
Outcome results
None listed