Pain After Laparoscopic Cholecystectomy With Bilateral Tranversus Abdominis Plane (TAP) Block Versus Local Anesthetic Infiltration

Postoperative Pain After Laparoscopic Cholecystectomy in Patients Receiving Bilateral Ultrasound-guided Transverse Abdominis Plane Block Compared With Local Anesthetic Infiltration of Trochar Insertion Sites With Ropivacaine 0.5%

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01204892

Enrollment

Registered

2010-09-17

Start date

2010-09-30

Completion date

2011-05-31

Last updated

2012-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pain

Brief summary

The purpose if to find out if analgesia with bilateral ultrasound-guided Tranversus Abdominis Plane (TAP) block with Ropivacaine 0.5% is better than analgesia with local infiltration of trochar sites with Ropivacaine 0.5% in patients undergoing laparoscopic cholecystectomy. Our hypothesis is that in laparoscopic cholecystectomy, bilateral TAP blocks will reduce postoperative pain scores when compared to conventional postoperative pain control with local infiltration of trochar insertion sites.

Detailed description

Interventions

PROCEDURETAP Block

Patient will received bilateral ultrasound-guided TAP block with total of 30 ml of ropivacaine 0.5% after induction of general anesthesia

PROCEDURELocal infiltration

20 ml of Ropivacaine 0.5% will be injected at port sites after induction of general anesthesia. 7 ml each for 10 mm ports, 3 ml each of 5 mm ports

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 64 Years

Healthy volunteers

Inclusion criteria

1. Patient ages 18-64 2. American Society of Anesthesiology Physical Status I, II or III 3. Inpatients scheduled to undergo laparoscopic cholecystectomy at Ben Taub General Hospital

Exclusion criteria

1. Open cholecystectomy - excluded due to increased levels of pain in open procedures 2. Scheduled for ambulatory surgery 3. Renal dysfunction (Serum Cr \> 1.2) - excluded due to potential altered metabolism of anesthetic and pain medications 4. Coagulopathy or anticoagulation - increased risk of bleeding from nerve block injection 5. Allergy or contraindication to any of the study medications or anesthetic agents 6. Chronic opioid analgesic use at home - excluded due to potential difficulty in assessing pain caused by the procedure alone 7. Patient inability to properly describe postoperative pain to investigators (language barrier, dementia, delirium, psychiatric disorder) 8. Pregnancy 9. Prisoners 10. Patient or surgeon refusal

Design outcomes

Primary

Measure	Time frame	Description
Pain	24 hours	Pain scores on NAS scale (0-10) at the following times: Preop, Time 0, Time 1, Time 2, Time 4, Time 8, Time 12, Time 24

Secondary

Measure	Time frame	Description
PONV (Postoperative nausea and vomiting)	24 hours	PONV events in first 24 hours
Narcotics use	24 hours	Fentanyl, morphine, and hydrocodone/apap total for 24 hours

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026