Brain Ischemia
Conditions
Keywords
cerebral ischemia, sevoflurane preconditioning, intracranial aneurysm surgery
Brief summary
The current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery.
Detailed description
The current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery. The patients with cerebral aneurysm will be recruited in current study. The sevoflurane preconditioning will be performed before the surgical procedure. The neurological injury biomarkers, such as S-100b and NSE will be detected. The neurological function and recovery will be assessed after the surgery.
Interventions
PROCEDURESev-I group
Sevoflurane will be given before the cerebral artery clip as a preconditioning procedure for the coming ischemia-reperfusion injury.
PROCEDURESevo continuous inhalation
Patients will receive the anesthesia with continuous inhalation of sevoflurane.
Sponsors
Xijing Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Patient under intracranial aneurysm surgery.
Exclusion criteria
* Patients who refused to participate or who had a history of chemotherapy/convulsions two weeks prior to admission, stroke/cardiopulmonary resuscitation/head trauma three months prior to admission, Alzheimer's disease, amyotrophic lateral sclerosis, and prior melanoma were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| S-100B,NSE | 7 days |
Secondary
| Measure | Time frame |
|---|---|
| Karnofsky Performance Scale,NIH stroke index, MMSE | 6 months |
Countries
China
Outcome results
None listed