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Managing Stress and Social Ties for Health Aging

Managing Stress and Social Ties for Health Aging

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01204021
Enrollment
26
Registered
2010-09-17
Start date
2008-05-31
Completion date
2010-08-31
Last updated
2016-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stress

Keywords

Stress, loneliness, social isolation, autonomic activity, inflammation, Perceived social isolation, Chronic stress

Brief summary

There has been a dramatic rise from 46% to 59% in the percentage of households with only 1-2 people from 1970 to 2000. A 40% increase in the number of people living alone is projected for 2010. Social isolation is consistently one of the strongest predictors mortality in older adults. Recent research is demonstrating that stress plays an important role linking social isolation with poor health. Socially isolated older adults are more likely to feel chronically stressed and overwhelmed with everyday life demands. Furthermore, isolated adults respond to stress differently, both psychologically and physiologically. Socially isolated and lonely older adults show long-term elevations in inflammatory cytokines, which are signaling molecules related by immune cells. These Inflammatory cytokines play a role in a number of age-related diseases including cardiovascular disease, type-2 diabetes and arthritis. Novel, readily useable interventions aimed at decreasing isolation and re-calibrating stress responses might be helpful to older adults. Tai Chi is an ancient Chinese form of calisthenics that promotes relaxation and decreases feelings of stress and as such, it may be a useful intervention for socially isolated, stressed older adults. However, its effects on stress responses are unknown. Tai Chi Chih (TCC) is a simplified, manualized, readily exportable form of Tai Chi particularly well-suited for older adults. This proposed study will test the effects of a TCC intervention with socially isolated older adults on loneliness, stress and health outcomes, including inflammatory assessment. Tai Chi-naïve participants who perceive themselves as socially isolated, as measured by the UCLA Loneliness Scale will be randomized to receive either Tai Chi or education control for a 12-week period. Subjects will undergo pre- and post-intervention stress assessment, including exposure to a psychological stress task, to assess whether Tai Chi affects how subjects physiologically and psychologically respond to stress.

Interventions

BEHAVIORALTai Chi Chih

12 weeks of weekly classes of Tai Chi Chih

BEHAVIORALStress Education Control

Weekly meetings, for 2 hours for 12 weeks discussing issues related to stress education.

Sponsors

University of California, Los Angeles
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Adults \> 60 years old * Have not done Tai Chi before * Live in Los Angeles area * Socially isolated * Women must be post menopausal

Exclusion criteria

* Any physical debility that limits Tai Chi performance; * Cognitive impairment (\< 23 on the Mini-Mental State Exam); * Current or recent history of smoking * Immune suppression resulting from neoplastic disease * Corticosteroid use or other therapy * Significant underlying illness that would interfere or prevent completion of the study * Acute conditions (e.g. viral infection w/in 2 weeks) that might confound interpretation of inflammatory data * Current or recent (within 1 month) use of illicit drugs.

Design outcomes

Primary

MeasureTime frame
Perceived Stress4-8 months

Secondary

MeasureTime frame
Autonomic Activity and inflammatory signalling4-8 months

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026