Diffuse Large B-cell Lymphoma
Conditions
Keywords
Diffuse large B cell lymphoma, central nervous system, prognosis
Brief summary
This study is to evaluate the incidence of central nervous system (CNS) relapse or metastasis in patients with diffuse large B-cell lymphoma.
Detailed description
We dichotomize patients according to the risk of CNS involvement. Then, we perform CNS evaluation in patients at risk of CNS involvement. We prospectively monitor whether CNS relapse or metastasis occurs in patients with diffuse large B-cell lymphoma
Interventions
PROCEDURECSF analysis
The cerebrospinal fluid will be evaluated via lumbar puncture.
Sponsors
Asan Medical Center
Yonsei University
National Cancer Center, Korea
Korea Cancer Center Hospital
Korea University
Samsung Medical Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Newly diagnosed patients with diffuse large B cell lymphoma 2. \> 20 years 3. life expectancy more than 6 months 4. Written informed consent
Exclusion criteria
1. Refusal to informed consent 2. Lymphomas other than diffuse large B cell lymphoma 3. Primary CNS lymphoma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| CNS relapse/involvement | Up to 2 years after participants are enrolled. | After enrollment, patients will be monitored to check the CNS relapse or involvement |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| survival | Up to 2 years after participants are enrolled | The survival outcome of patients will be monitored. |
Countries
South Korea
Outcome results
None listed