Community-acquired Pneumonia
Conditions
Keywords
children aged under 5 years, Non-severe
Brief summary
The purpose of the study is to compare the clinical efficacy of amoxicillin given twice or three times a day to children with non-severe community-acquired pneumonia.
Interventions
DRUGAmoxicillin
amoxicillin 50mg/kg/day given in two different administration schemes
Sponsors
Federal University of Bahia
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
2 Months to 59 Months
Healthy volunteers
No
Inclusion criteria
* Children aged between 2 and 59 months * Report of respiratory complaints * Presence of pulmonary infiltrate on chest x-ray taken on admission and read by the pediatrician on duty
Exclusion criteria
* lower chest indrawing * danger signs (inability to drink, convulsions, somnolence, central cyanosis, grunting in a calm child) * diagnosed underlying chronic diseases (anatomic abnormalities of the respiratory tract, chronic pulmonary illness besides asthma, immunological defects, progressing neurological disorders, psychomotor retardation, heart disease with clinical repercussion, hemoglobinopathy, liver or kidney disease) * severe malnutrition * other concurrent infection * hospitalization during the previous 7 days * amoxicillin or similar antibiotic use during the last 48 hours * allergy to amoxicillin * history of aspiration
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| clinical efficacy | 48 hours | resolution of fever, difficulty breathing and tachypnea |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Resolution of cough | 96 hours | Disappearance of cough |
Countries
Brazil
Outcome results
None listed