POCD in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia

Incidence of Postoperative Cognitive Dysfunction in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia: A Randomized, Controlled Trial

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01199913

Enrollment

110

Registered

2010-09-13

Start date

2010-08-31

Completion date

2014-08-31

Last updated

2014-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

1. Postoperative Cognitive Dysfunction

Keywords

problems with thinking after surgery;

Brief summary

The use of desflurane in elderly subjects (\>65 years old) undergoing general anesthesia with endotracheal intubation will result in decreased POCD compared to sevoflurane if the patient's MAP is within 20% of the patient's baseline and the cerebral suppression state index stays within the moderately anesthetized range during general anesthesia.

Interventions

OTHERThe intervention will be Mini-Mental Status Examination (MMSE)

A questionnaire given to the study patient before and after the anesthetic at 1, 6 and 24 hours.

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adult patients (\>65 years old) * Scheduled for elective surgery requiring general anesthesia at LLUMC HSH * Airway management expected to include endotracheal intubation * Expected surgical duration 120 to 240 minutes

Exclusion criteria

* Pre-existing significant psychiatric disease or mental status changes * Clinically significant cardiovascular, respiratory, hepatic, renal,neurological, psychiatric, or metabolic disease * Patient's weighing \>50% ideal body weight * Men: Ideal Body Weight (in kilograms) = 50 + 2.3 kg per inch over 5 feet * Women: Ideal Body Weight (in kilograms) = 45.5 + 2.3kg per inch over 5 feet * Patients who have undergone a general anesthetic within the past 7 days * Patient refusal

Design outcomes

Primary

Measure	Time frame	Description
POCD in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia	Both groups will complete the MMSE at 1, 6, and 24 hours after the end of anesthesia or to disharge up to 7 days.	The primary outcome measure will be changes in cognitive function after anesthesia as measured by MMSE.

Secondary

Measure	Time frame
Secondary outcome measures will include: 1) time to extubation, anesthetic complications (e.g. coughing during extubation), 2) time to readiness for discharge from PACU, 3) length of hospital stay, and 4) any postoperative complications.	24 hours to 7 days

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 8, 2026