Major Depressive Disorder
Conditions
Keywords
repetitive Transcranial Magnetic Stimulation, Major Depressive Disorder
Brief summary
The objective of this study is to investigate the antidepressant efficacy of rTMS, and to assess cortical metabolism before and after rTMS sessions in patients with major depression. We also aimed to investigate differences between the responders and nonresponders to rTMS and what would predict clinical response to rTMS.
Detailed description
The specific aims of this study is to: (1) evaluate the antidepressant efficacy of rTMS on major depression; (2) evaluate the effects of rTMS on cognitive function in depressive patients; (3) assess the effects of rTMS on cerebral glucose metabolism in depressive patients as measured by 18FDG PET; (4) investigate the differences of the regional cerebral glucose uptake changes during rTMS between responders and nonresponders to rTMS.
Interventions
DEVICErepetitive Transcranial Magnetic Stimulation
10 times repetitive TMS, high frequency
Sponsors
Samsung Medical Center
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Twenty patients fulfilling the diagnostic criteria of major depression according to DSM IV will be enrolled in the study. * Antidepressant medication will be maintained throughout the study period.
Exclusion criteria
*
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hamilton depression rating scale (HAM-D 17) | baseline, 1, 2, and 4 weeks after TMS | measuring instrument of severity of depressive symptoms |
Countries
South Korea
Contacts
Primary ContactDoh Kwan Kim, M.D., Ph.D.
Outcome results
None listed