Denture Stomatitis
Conditions
Keywords
denture stomatitis, nystatin, garlic
Brief summary
The aim of the present study was to compare the effect of aqueous extract of garlic with nystatin mouthwash in denture stomatitis.
Detailed description
Denture stomatitis is the most common form of chronic oral candidiasis manifested as chronic inflammation of the mucous membrane t supporting the movable prosthesis that may have a local or systemic nature. This inflammation is presented as mucous erythema and occasionally with pain and burning. The standard treatment for denture stomatitis is administration of nystatin which is accompanied with complications such as bitter taste as well as the high number of drug application that result in reduced tendency of patients in using this medication hence, efforts are continuously being made to substitute other types of therapies for this condition.
Interventions
DRUGgarlic , nystatin
mouthwash
Sponsors
Qazvin University Of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 40 years of age and older * confirm of denture stomatitis by the oral medicine specialists
Exclusion criteria
* Patients with a history of using anti-fungal drugs, antibiotics, and corticosteroid within the previous month * allergy to garlic and nystatin mouthwash * immunodeficiency * uncontrolled diabetes * those with garlic rich diet * inability in using mouthwash * loose and discolored dentures * psychologic disorder and alzheimer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| reduction of diameter of erythematous lesion under denture | first week | measuring erythematous lesion by visual and then photography and a colis |
Secondary
| Measure | Time frame |
|---|---|
| complete relief of erythematous lesions | fourth week |
Countries
Iran
Outcome results
None listed