Evaluation of Surfactant Protein B in the Differential Diagnostics of Dyspnea

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01197586

Enrollment

Registered

2010-09-09

Start date

2010-10-31

Completion date

2011-12-31

Last updated

2013-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Disease, Dyspnea, Pulmonary Disease

Keywords

surfactant protein B, differential diagnostics

Brief summary

Establishing new biochemical markers in the differential diagnostics and risk stratification in heterogeneous patient collectives is becoming more and more important. The markers should be objective, reliable, reproducible, quick and cost effective as well as specific and sensitive. Concerning the differential diagnostics of dyspnea, NT-pro-BNP plays the most important role for the evaluation of a cardiac origin. However, a corresponding biochemical marker for pulmonary stress is lacking. The aim of the study at hand therefore was the evaluation of surfactant protein B in the differential diagnostics of pulmonary and cardiac diseases.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* patients presenting with dyspnea and giving informed consent

Exclusion criteria

* outpatients * lack or doubt of legal competence * indication for mechanical ventilation * pregnancy * palliative patients * CPAP/LTOT * BMI \> 30 kg/m2 * sepsis * anemia * dialysis

Design outcomes

Primary

Measure	Time frame
Surfactant protein B serum levels	Days 1, 3 and 7

Countries

Germany

Outcome results