Acute Phonotrauma
Conditions
Keywords
acute phonotrauma, computer modeling, resonant voice, breathy voice, voice rest, relaxation
Brief summary
The purpose of this study is to generate a technology that will allow clinicians to prescribe behavioral treatment that should optimize tissue healing for both acute and chronic phonotrauma. In this study, we propose to (1): establish a non-invasive methodology for estimating overall mechanical dose during phonation, and component metrics of phonatory mechanical dose (e.g., distance dose, energy dissipation dose and time dose) from high speed imaging data and aeromechanical modeling, for a range of vocal fold configurations (Experiment 1); (2): identify mathematical relations between treatment dose parameters, inflammatory state of the tissue and time-varying biological consequences in the tissue, up to 2 wk following acute phonotrauma (Experiment 2); (3): develop a hybrid physical-biological model of vocal fold inflammation and treatment to identify treatment modalities that should optimize post-traumatic wound healing at 2 wk, for a range of acute phonotraumatic conditions (Experiment 3-no human subject involved), and (4): provide a preliminary test of the hybrid treatment models' ability to predict idealized treatment outcome in human subjects, and calibrate the model as needed iteratively to achieve a match between predicted and obtained outcomes (Experiment 4).
Interventions
BEHAVIORALBreathy voice
A 4-hr breathy voice exercise will be prescribed to subjects following vocal loading.
BEHAVIORALRelaxation exercise
A 4-hr relaxation exercise will be prescribed to subjects following vocal loading.
BEHAVIORALresonant voice
A 4-hr resonant voice exercise will be prescribed to subjects following vocal loading.
BEHAVIORALvoice rest
A 4-hr voice rest will be prescribed to subjects following vocal loading.
BEHAVIORALResonant voice and relaxation exercise
A 4-hr resonant voice and relaxation exercise will be prescribed to subjects following vocal loading.
Sponsors
National Institute on Deafness and Other Communication Disorders (NIDCD)
McGill University
Purdue University
University of Pittsburgh
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy females * ages 18-40 * generally healthy * normal hearing bilaterally at 20 dB to 8,000 Hz * have ability to produce resonant voice during training as determined by the examiner perceptually * Tolerate rigid and nasal endoscopy without anesthesia to the larynx nasal patency allowing for the passage of an endoscope unilaterally
Exclusion criteria
* Smoking within the past five yr * Failing a hearing screening test * Having current chronic voice problems * Having current medications that are determined to possibly influence voice * Having heightened gag reflex * Having known or suspected allergy to anesthetics * Pregnancy reported
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biomarker levels in laryngeal secretion | up to 2 months |
Countries
United States
Outcome results
None listed