Pharmacokinetic of Sevoflurane During a 48h Sedation in Intensive Care Unit With AnaConDa®

Pharmacokinetic of Sevoflurane During a 48h Sedation in ICU With AnaConDa®

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01196754

Acronym

Anaconda

Enrollment

Registered

2010-09-08

Start date

2008-03-31

Completion date

2009-05-31

Last updated

2010-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sedation

Keywords

Pharmacokinetics, Sevoflurane, Fluorides, Sedation, Adult patients with a predicted sedation more than 48 h, Stable respiratory and hemodynamic conditions for SBT, Consent of patients, Arterial line

Brief summary

This is a prospective clinical monocentric study in ICU with sedated ventilated patients with sevoflurane during 48 h with the AnaConda® system, establishing pharmacokinetic model of sevoflurane.

Detailed description

Prospective clinical monocentric study in ICU with sedated ventilated patients with sevoflurane during 48 h with the AnaConda® system, establishing pharmacokinetic model of sévoflurane and its metabolites (hydroxyfluroisopropanol, fluoride)

Interventions

OTHERsevoflurane

Study design

Primary purpose

SCREENING

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adult patients ventilated more than 48 h * Stable respiratory and hemodynamic conditions * Consent of patients or family * Arterial line

Exclusion criteria

* Acute kidney injury * Obesity * Sevoflurane anaphylaxia

Design outcomes

Primary

Measure	Time frame
Determination of plasmatic concentrations of sévoflurane at different times of a 48h sedation of sévoflurane.	during 48 hours

Secondary

Measure	Time frame
Determination of plasmatic concentrations of HFIP and fluoride at different times of a 48h sedation of sévoflurane. Determination of a pharmacokinetic model of sévoflurane.	during 48 hours

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026