Dietary Intervention With Shop Model - SHOPUS

Conditions

Obesity

Brief summary

The objective is to investigate whether New Nordic Diet (NND) versus Average Danish Diet (ADD) in adults (18-65 y) with central obesity and components of the metabolic syndrome can improve body weight loss and risk markers of the metabolic syndrome, type 2 diabetes and cardiovascular diseases.

Hjorth MF, Christensen L, Larsen TM, Roager HM, Krych L, Kot W, Nielsen DS, Ritz C, Astrup A.

2020-05-0138 citations

10.1093/ajcn/nqaa007

Pretreatment fasting plasma glucose and insulin modify dietary weight loss success: results from 3 randomized clinical trials.

Hjorth MF, Ritz C, Blaak EE, Saris WH, Langin D, Poulsen SK, Larsen TM, Sørensen TI, Zohar Y, Astrup A.

2017-07-0574 citations

10.3945/ajcn.117.155200

Long-term adherence to the New Nordic Diet and the effects on body weight, anthropometry and blood pressure: a 12-month follow-up study.

Poulsen SK, Crone C, Astrup A, Larsen TM.

2014-03-2527 citations

10.1007/s00394-014-0686-z

Health effect of the New Nordic Diet in adults with increased waist circumference: a 6-mo randomized controlled trial.

Poulsen SK, Due A, Jordy AB, Kiens B, Stark KD, Stender S, Holst C, Astrup A, Larsen TM.

2013-11-20140 citations

10.3945/ajcn.113.069393

Interventions

BEHAVIORALDietary intervention

Instruction to diet for 6 month

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* abdominal obesity

Exclusion criteria

* BMI \> 45, previous weight change

Design outcomes

Primary

Measure	Time frame	Description
Change in body weight (kg)	26 weeks	Change in body weight from randomization to end of intervention

Secondary

Measure	Time frame	Description
Change in body fat percentage	26 weeks	Change in body fat percentage (DEXA-scanning)
Dietary compliance	26 weeks	Level of dietary compliance
Changes in components of the metabolic syndrome	26 weeks	Changes in the number of components of the metabolic syndrome
Achievement of 5% weight loss	26 weeks	Achievement of 5% weight loss from randomization to end of intervention

Other

Measure	Time frame	Description
Microbial composition and association with Body weight change	26 weeks	Diet specific change in body weight according to relative abundance of microbial bacteria, e.g., baseline Prevotella/Bacteroides ratio \[proxy for enterotypes\])
Molecular regulation of glucose homeostasis	26 weeks	Diet specific molecular regulation in adipose and muscle tissue
Human salivary amylase gene copy number (AMY1 CN) and association with Body weight change [ Time Frame: 26 weeks ]	26 weeks	Diet specific change in body weight according to AMY1 CN
Change in gastrointestinal microbial composition	26 weeks	Diet specific changes in relative abundance of microbial bacteria

Countries

Denmark

Outcome results

None listed