Polycystic Ovary Syndrome
Conditions
Keywords
PCOS
Brief summary
Women with polycystic ovary syndrome (PCOS) are more often overweight or obese and are more insulin resistant than women without the condition and may be at greater risk of developing cardiovascular disease. It is not know whether it is the overweight and insulin resistant component of PCOS, or PCOS per se which leads to the greater cardiovascular disease risk. The aim of this study was to examine cardiovascular risk markers in women with PCOS versus a control population matched for body mass index (BMI), and or, insulin resistance
Interventions
None listed
Sponsors
University College Dublin
The Adelaide and Meath Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Had a positive diagnosis of PCOS as defined according to the NIH criteria as chronic oligomenorrhoea (\< 9 menstrual cycles per year) and clinical and/or biochemical evidence of hyperandrogenism, in the absence of other disorders causing the same phenotype. Clinical criteria included hirsutism with a Ferriman-Galwey score greater than 9, acne or male pattern alopecia; biochemical criteria included total-testosterone, androstenedione or dehydroepiandrosterone sulphate (DHEAS) greater than the laboratory reference range. * Were between the ages of 18 and 40
Exclusion criteria
* Were under 18 years or greater than 40 years old, * Were non-Caucasian * Were pregnant, lactating or trying to conceive * Had a body mass index (BMI) \<18kg/m2 or \>50kg/m2 * Had a recent illness or any chronic illness likely to influence results * Were taking hormonal contraception
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of Insulin resistance in women with PCOS compared with BMI and age matched controls | Recruitment ran from Nov 2006-July 2008; Each subject attended the study location fasting on one occasion | Subjects underwent a standard 75g oral glucose tolerance test (OGTT) and blood were taken fasting and at 2 hours. Surrogate markers of insulin resistance (HOMA) and insulin sensitivity (Avignon index of Insulin Sensitivity; QUICKI) were calculated |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of lipid profile in women with PCOS compared with age matched controls | Recruitment ran from Nov 2006-July 2008; Each subject attended the study location fasting on one occasion | Bloods were taken in the fasted state and circulating concentrations of lipids assessed |
| Assessment of concentrations of androgens in women with PCOS compared with controls | Recruitment ran from Nov 2006-July 2008; Each subject attended the study location fasting on one occasion | Bloods were taken in the fasted state and circulating concentrations of androgens (DHEAS, testosterone, androstenedione) were assessed |
| Assessment of inflammatory profile in women with PCOS compared with controls | Recruitment ran from Nov 2006-July 2008; Each subject attended the study location fasting on one occasion | Bloods were taken in the fasted state and circulating concetrations of several important markers of inflammation as well as key adipokines were assessed |
Countries
Ireland
Outcome results
None listed