Chronic Obstructive Pulmonary Disease (COPD), Obstructive Sleep Apnea Syndrome (OSAS)
Conditions
Keywords
COPD patients, OSAS patients, cardiovascular surgery, Endothelial function
Brief summary
The aim of this clinical trial is to evaluate the effect of chronic obstructive pulmonary disease (COPD) and/or obstructive sleep apnea syndrome (OSAS) on the endothelial function, before cardiovascular surgery, compared to non COPD non OSAS patients undergoing also a cardiovascular surgery, by an observational physiological study. An interim analysis will be performed when 100 patients will be included.
Detailed description
Secondary objectives of this clinical trial : * To evaluate the effect of COPD and/or OSAS on the systemic inflammation, insulin-resistance and oxydative stress, in comparison with non COPD non OSAS patients. * To evaluate the effect of COPD and/or OSAS on the inflammation and oxydative stress of the adipose tissue, in comparison with non COPD non OSAS patients. * To validate the STOP-BANG questionnaire in patients undergoing a cardiovascular surgery
Interventions
None listed
Sponsors
University Hospital, Grenoble
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Men or women between 18 and 80 years old * Patient with planned coronary artery bypass graft surgery * Patient with planned peripheral vascular surgery * Patient with aortic surgery
Exclusion criteria
* Patient with aortic or mitral valvular replacement * Patient with emergency peripheral valvular surgery * Patient with emergency coronary artery bypass graft surgery * Patient with evolutive malignancy disease * Pregnant or lactating women * Patient with inadvisable bronchodilator (used for functional respiratory) exploration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the percent of peripheral arterial tone (PAT) in COPD and/or OSAS patients compared to non COPD non OSAS patients. | one week before their cardiovascular surgery |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of the systemic inflammation, insulin-resistance and oxidative stress occurring during COPD and/or OSAS patients compared to non COPD non OSAS patients. | one week before their cardiovascular surgery |
| Evaluation of adipose tissue inflammation and oxidative stress occurring during COPD and/or OSAS patients compared to non COPD non OSAS patients. | one week before their cardiovascular surgery |
| Polysomnography | one week before their cardiovascular surgery |
| Functional respiratory exploration | one week before their cardiovascular surgery |
Countries
France
Outcome results
None listed