Scoring System for Inhalation Injury

Burn Multicenter Proposal: Development of an Inhalation Injury Scoring System to Predict Severity of Inhalation Injury

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01194024

Enrollment

108

Registered

2010-09-02

Start date

2011-11-30

Completion date

2019-09-29

Last updated

2021-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inhalation Injury

Keywords

Inhalation Injury, Smoke, Inhalation Injury, Acute

Brief summary

The goal of this multicenter study is to develop a standardized scoring system for inhalation injury that can be used both to quantify and predict injury severity inhalation injury in adults over 18 years of age. A model will be developed based on clinical, radiographic, bronchoscopic, and biochemical parameters that will predict the severity of inhalation injury with greater than 80% predictive accuracy

Detailed description

Interventions

OTHERStandard of Care

bronchoscopy with collection of bronchioalveolar lavage specimen, blood samples, High-Resolution spiral computed tomography(CT)

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Injury consistent with inhalation of smoke or products of combustion * Requires intubation within 24 hours of injury * Meets one of the following 4 criteria 1. history of closed space injury 2. carbonaceous sputum 3. elevated carboxyhemoglobin 4. dx of inhalation injury is considered likely by investigator

Exclusion criteria

* ≤ 17 years of age * Prisoner

Design outcomes

Primary

Measure	Time frame	Description
Development of a diagnostic model to predict the severity of inhalation injury	within 48 hours of admission	The development of a diagnostic model to predict the severity of inhalation injury based on demographics, characteristics of injury, bronchoscopy, CT scan, and inflammatory markers.

Secondary

Measure	Time frame	Description
Impact of inhalation injury	at discharge	Assessment of the impact of inhalation injury on the incidence of pneumonia, acute respiratory distress syndrome (ARDS), and acute lung injury (ALI).

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026