Protein-energy; Imbalance
Conditions
Keywords
Protein requirement, Elderly women, Indicator amino acid oxidation
Brief summary
The purpose of this study is to evaluate dietary protein requirements in elderly women aged 80 years and older using the indicator amino acid oxidation technique. Hypothesis to be tested: Protein requirement for elderly women is higher than the estimated average requirement of 0.66 g∙kg-1∙d-1 protein. The recommended protein intake for elderly women is higher than the recommended dietary allowance of 0.80 g∙kg-1∙d-1 protein.
Detailed description
There is currently considerable debate regarding the accuracy of the estimated average requirement (EAR) and the recommended dietary allowance (RDA) for older people. Very limited data obtained from older individuals are available to support the assumption that age does not affect protein requirement. Existing method like nitrogen balance has inherent limitations that diminish it from being considered a reference method. Indicator amino acid oxidation technique is emerging as an alternative method to measure dietary protein requirement. It is more accurate and less demanding. The current study will be the first time this technique is used with elderly adults and will provide an important foundation for geriatric nutrition research.
Interventions
DIETARY_SUPPLEMENTdietary control
Seven dietary protein levels will be tested randomly on the 7 testing days: 0.10, 0.30, 0.60, 0.90, 1.2, 1.5, and 1.8 g∙kg-1∙d-1.
Sponsors
National Center for Research Resources (NCRR)
Purdue University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
80 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Female * Age range: 80 yrs and older * Body mass index between 22-30 * Weight stable 4.5 kg weight gain or loss within the last 6 month * Non-smoking within the last 6 month * Ambulatory * Clinically normal blood profiles within 10% of clinical normalc. * No diseases or not taking medications known to influence protein or energy metabolism, * Willingness and ability to consume food provided and not allergic to phenylalanine * Continent, strong bladder control
Exclusion criteria
* Male, * Gained or lost more than 4.5 kg of body weight within the last 6 months, * Non-ambulatory (i.e. bedridden, wheel-chair bound), * Clinically abnormal blood profiles as identified by our study physician, Arthur Rosen, MD
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| dietary protein requirement in older women | 3 month | Dietary protein requirement is assessed by the subjects' differential response to different dietary protein intake |
Countries
United States
Outcome results
None listed