Overweight
Conditions
Brief summary
Preliminary studies in rats and mice indicate that calanus oil reduce accumulation of intra-abdominal fat. Pilot studies in humans have shown no adverse effects. In the present study 120 subjects, males and females, 20-65 years old, BMI 25-30 kg/m2 will be included and given calanus oli 1 g twice daily versus placebo for 1 year. The hypothesis is that calanus oil will reduce intra-abdominal fat, improve glucose tolerance and lipid profile.
Interventions
DIETARY_SUPPLEMENTcalanus oil
1 gram twice daily
DIETARY_SUPPLEMENTolive oil
1 gram twice daily
Sponsors
University of Tromso
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Body Mass Index (BMI) 25-30 kg/m2 * age 20-65 years
Exclusion criteria
* diabetes * coronary heart disease last 12 months * unstable angina pectoris * cancer diagnosed the last 5 years * use of lipid lowering drugs * seafood allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intra-abdominal fat as measured with CT scan | at the end of 12 months intervention |
Secondary
| Measure | Time frame |
|---|---|
| oral glucose tolerance test | at the end of 12 months intervention |
| lipid status | at the end of 12 months intervention |
| systolic and diastolic blood pressure | at the end of 12 months intervention |
| markers of inflammation - C-reactive protein (CRP) | at the end of 12 months intervention |
| body weight | at the end of 12 months intervention |
Countries
Norway
Outcome results
None listed