Efficacy of Albendazole to Treat Intestinal Helminths and Its Effect on Gut Microflora

Effect of Intestinal Helminths on Gut Microflora

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01192802

Enrollment

200

Registered

2010-09-01

Start date

2010-08-31

Completion date

2012-07-31

Last updated

2013-01-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Helminthiasis, Intestinal Diseases

Keywords

albendazole, ascaris, trichiurus, hookworms

Brief summary

Albendazole is a main anti-helminth, however there is a lack of data regarding its efficacy in the school children population. The aim of this study is to evaluate the efficacy of the albendazole one versus two and three doses, in school children infected with intestinal helminth.

Interventions

DRUGalbendazole

1 tablet of 400 mg of albendazole per day for three consecutive days

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

4 Years to 14 Years

Healthy volunteers

Yes

Inclusion criteria

* presence of intestinal helminths eggs in the stool

Exclusion criteria

* allergy to imidazole derivate * No intestinal helminths

Design outcomes

Primary

Measure	Time frame
parasite cleared and reduced up to 80% at day 42	42 days

Secondary

Measure	Time frame	Description
Prevalence of major gut bacteria	42 days	Change in the prevalence of major gut bacteria after antihelminth treatment.

Countries

Gabon

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 8, 2026