Eosinophil Markers and Development of Disease in Allergic Rhinitis

Eosinophil Markers and Development of Disease in Allergic Rhinitis. A 15-year Follow-up of Patients With Grass Pollen Induced Hayfever.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01192386

Enrollment

Registered

2010-09-01

Start date

2010-05-31

Completion date

2010-05-31

Last updated

2010-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Seasonal Allergic Rhinitis

Brief summary

Inflammatory proteins from eosinophil granulocytes in blood from patients with seasonal allergic hayfever have been shown to predict development of asthma at a six-year follow-up. This study is a 15-year follow-up of the same patients to verify earlier results and study disease development.

Detailed description

The study consists of a single visit at which patients fill in a questionnaire on actual hayfever and asthma symptoms as well as current treatment. Blood samples and nasal lavages are drawn and analysed for eosinophils as well as eosinophil cationic protein and tryptase. Spirometry is performed. If patients use drugs which can interfere with results, ie. corticosteroids or beta-agonists, biochemistry and/or spirometry are omitted.

Interventions

None listed

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Participant in earlier study (1995)

Exclusion criteria

* Treatment with any kind of corticosteroid within two months will exclude from study of inflammatory parameters

Design outcomes

Primary

Measure	Time frame	Description
Asthma morbidity	Single measurement - May 2010	Patients are asked whether they have experienced asthmatic symptoms or have been disgnosed with asthma within the latest 15 years

Secondary

Measure	Time frame	Description
Rhinitis morbidity	Single measurement - May 2010	Patients are asked for current hayfever symptoms

Outcome results