Knee Arthroplasty, Postoperative Pain
Conditions
Keywords
Adductor-Canal-Blockade, postoperative pain, US-guided nerve block, revision knee arthroplasty
Brief summary
The purpose of this study is to determine whether Adductor-Canal-Blockade is effective at reducing pain and morphine consumption after revision knee arthroplasty.
Interventions
US-guided Adductor-Canal-Blockade with ropivacaine 7,5 mg/ml
PROCEDUREAdductor-Canal-blockade with saline
US-guided Adductor-Canal-blockade with saline
Sponsors
Rigshospitalet, Denmark
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Revision Knee Arthroplasty in general anaesthesia * American society of anesthesiologists (ASA) 1-3 * BMI 18-40 * Written informed consent
Exclusion criteria
* Can not cooperate to the exam * Do not speak or understand Danish * Drug allergy * Alcohol or drug abuse
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain during 45 degrees active flexion of the knee | 4 hours postoperative | 0-100 mm at a visual analogue scale (VAS), at 4 hours postoperative. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain during rest | 1-8 hours postoperative | 0-100 mm at a visual analogue scale (VAS), registered at the intervals 1, 2, 4, 6 and 8 hours postoperative, calculated as the area under the curve (AUC) for the interval 1-8 hours postoperative. |
| Total morphine consumption | 0-24 hours postoperative | Total morphine consumption at the intervals 0-8, 8-24 and 0-24 hours postoperative. |
| Postoperative nausea | 1-8 hours postoperative | Nausea scores(0-3)registered at 1,2,4,6 and 8 hours postoperative, calculated as mean value for the interval 1-8 hours postoperative. |
| Pain during 45 degrees active flexion of the knee | 1-8 hours postoperative | 0-100 mm at a visual analogue scale (VAS), registered at the intervals 1, 2, 4, 6 and 8 hours postoperative, calculated as the area under the curve (AUC) for the interval 1-8 hours postoperative. |
| Zofran consumption | 0-24 hours postoperative | Total zofran consumption at the intervals 0-8, 8-24 and 0-24 hours postoperative. |
| Sedation | 1-8 hours postoperative | Sedation score (0-3) registered at 1,2,4,6 and 8 hours postoperative, calculated as the mean value for the interval 1-8 hours postoperative. |
| Postoperative vomiting | 0-24 hours postoperative | Number of vomiting episodes at the intervals 0-8, 8-24 and 0-24 hours postoperative. |
Countries
Denmark
Outcome results
None listed