General Anesthesia
Conditions
Keywords
breath, propofol, general anesthesia
Brief summary
This trial investigates the relationship between concentrations of the anesthetic drug propofol in exhaled breath, blood and drug effect in volunteers undergoing general anesthesia. The main goal of this study is to develop a pharmacokinetic - and dynamic model for propofol in exhaled breath.
Interventions
Volunteers will undergo propofol anesthesia for 90 min.
Sponsors
University of California, San Francisco
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 18 years of age * Written informed consent * Ability and willingness to give written informed consent * American Society of Anesthesiologists (ASA) risk score I
Exclusion criteria
* Volunteers ASA physical status II - III * Pregnancy * Volunteers with history of neurological disease or stroke * Volunteers with a history of recreational drug abuse * Volunteers with a history of alcohol abuse * Smokers * Anesthesia within 6 months * Known drug allergies * History of adverse events during general anesthesia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Exhaled propofol (parts per billion) | Continuous measurement over 90 min |
| Processed electroencephalography (Bispectral Index (0-100)): Change from baseline during anesthesia | continuous over 90 min |
Countries
United States
Outcome results
None listed