Rectal Cancer
Conditions
Keywords
Direct pO2 Measurements, 10-121
Brief summary
The purpose of this study is to see if the cells in rectal cancer are oxygen-starved, or hypoxic. We know that as cancers grow bigger, parts of them are cut off from the oxygen supply and they become hypoxic, basically, lacking oxygen. Research has shown that cells that are oxygen-starved respond differently to treatment such as chemotherapy and radiation when compared to cells that are oxygen rich.
Interventions
PROCEDUREEppendorf hypoximeter
Patients consented to the protocol will proceed to their surgery date without any change in the standard preoperative period. After arriving in the operating room, the patient will undergo intravenous general anesthesia (or spinal/epidural anesthesia) by the anesthesiologist and will receive 40% oxygen. At this time, the principal investigator (along with the assistance of the operating surgeon and a member of the Department of Medical Physics) will use the Eppendorf hypoximeter to gather pO2 measurements. We anticipate that this will add no more than fifteen minutes to the planned procedure. Once the measurements are collected, the anesthesia will be adjusted as appropriate for the surgery and the procedure will continue as usual.
Sponsors
Memorial Sloan Kettering Cancer Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 89 Years
Healthy volunteers
No
Inclusion criteria
* Biopsy proven adenocarcinoma of the rectum. If a biopsy was taken at an outside hospital, the slides and diagnosis will be reviewed and confirmed by a pathologist at MSKCC. * Mid to distal rectal tumors not requiring pre-op radiation or chemotherapy * Age ≥ 18 * Age \< 90 * Karnofsky performance status ≥ 60 * Ability to understand and the willingness to sign a written informed consent document.
Exclusion criteria
* Current pregnancy * Uncontrolled intercurrent illness that would limit compliance with study requirements.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measure pO2 in rectal cancers | 2 years | Measure pO2 in rectal cancers |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlate immunohistochemical analysis of endogenous markers of hypoxia | 2 years | with direct tumor hypoximetry in tumor and normal tissue. |
Countries
United States
Outcome results
None listed