Hyperalgesia
Conditions
Keywords
remifentanil, hyperalgesia
Brief summary
The investigators hypothesize that propofol infusion during surgery can affect the remifentanil hyperalgesia compared to sevoflurane inhalation.The outcome will be measured by a verbal numerical rating score (VNRS) and mechanical punctuating pain by electronic von frey filament.
Interventions
DRUGpropofol, sevoflurane
Remifentanil will be infused intraoperatively at 0.2 ㎍/㎏/min (group1 and 2) group 1 (Active Comparator, sevoflurane)will be infused propofol intraoperatively. group 2(Experimental, propofol) will be inhaled sevoflurane intraoperatively.
Sponsors
Gangnam Severance Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing thyroidectomy * Age 20-65 * American Society of Anesthesiologists physical status classification I or II
Exclusion criteria
* History of chronic pain, Regular use of analgesic, antiepileptic or antidepressive drugs * History of drug & alcohol abuse * Psychiatric disorder * Use of opioids within 24hrs * Renal disease with decreased glomerular filtrate ratio * Neuromuscular disease, Severe cardiac disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tactile pain thresholds adjacent to the surgical wound assessed by von Frey hair before the induction and at postoperative 24 & 48 hrs | postoperative 48 hrs |
Countries
South Korea
Contacts
Primary Contactyoung ju won, MD.
Backup Contactyuen hee shim, MD.
Outcome results
None listed