Major Depressive Disorder
Conditions
Brief summary
Sleep deprivation can acutely reverse depressive symptoms in patients with major depression. Although underlying mechanisms of the antidepressant action in sleep deprivation are unclear, many of these observations can be explained by abnormal slow wave homeostasis. This study will test the prediction that selectively reducing slow waves during sleep (slow wave deprivation; SWD), without disrupting total sleep time, will yield an antidepressant effect.
Detailed description
see above
Interventions
DEVICESlow-wave deprivation
Using acoustic tones to suppress slow-wave sleep
Sponsors
National Institutes of Health (NIH)
University of Wisconsin, Madison
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
SINGLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Among the inclusion criteria will be: * age range 18-35 years * right handedness * major depressive disorder according to DSM-IV (Diagnostic and Statical Manual-Revision 4) criteria (as determined by the Structured Clinical Interview for Diagnostic and Statical Manual-Revision 4), with Hamilton Rating Scale for \*Depression scores of at least 18 on the first 17 items * no psychotropic medications for at least 4 weeks * no joint and muscular di * normal hearing * regular bedtimes and sleep duration, no time zone shifts in the last three weeks.
Exclusion criteria
* Diabetes requiring insulin treatment * A serious heart disorder or subjects who have had a heart attack within the last 3 months * A diagnosis of cancer in the past 3 years and/or has active neoplastic disease * Clinically significant abnormalities on pre-study physical exam or physician evaluation * Subjects who meet DSM-IV (Diagnostic and Statical Manual-Revision 4) criteria for alcohol/drug abuse problems within the last six months or are currently using illegal drugs. * Female subjects of child-bearing potential who are pregnant or planning to become pregnant. * Women of child-bearing must be practicing a medically acceptable form of birth control. * Women of childbearing potential will be questioned about pregnancy status and form of birth control to be used at each visit. * Women who are unsure of their pregnancy status will be given a urine pregnancy test. * Subjects taking investigational medications * Subjects currently undergoing electroconvulsive therapy (ECT) or therapeutic transcranial magnetic stimulation (TMS). * Subjects who regularly perform night or late evening shift work (e.g. - second or third shifts) or have had travel with time zone shifts \>3h in the last 3 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale | 24 hours |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Inventory of Depressive Symptomology | 24 hours | rating scale of mood |
Countries
United States
Outcome results
None listed