CT Coronary Angiography and Computational Fluid Dynamics

Non-invasive Functional Assessment of Coronary Stenoses Using CT Coronary Angiography and Computational Fluid Dynamics

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01189331

Enrollment

103

Registered

2010-08-26

Start date

2009-10-13

Completion date

2020-12-31

Last updated

2021-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Keywords

Coronary artery disease, CT, Computational flow dynamics

Brief summary

Angiographically obtained fractional flow reserve(FFR) could provide functional and clinical information about stenotic lesion, but the invasiveness and measuring difficulty of FFR make it unfamiliar to perform. CT coronary angiography is non-invasive tool to evaluate lesion severity and lately developing computational fluid dynamics could provide functional information. The investigators build a patient specific model of computational fluid dynamics by CT coronary angiography and evaluate the functional significance by measuring fractional flow reserve via CT coronary angiography and computational fluid dynamics, and investigate its long-term prognostic implications.

Interventions

DEVICECT coronary angiography and computational fluid dynamics

Evaluate coronary blood flow dynamics by CT coronary angiography and computational fluid dynamics

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

SINGLE (Investigator)

Masking description

With masking value of FFR derived from coronary CT angiography to the investigators, FFR is measured and patients have been followed-up.

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Significant stenosis at CT angiography * Normal ejection fraction on echocardiography * Informed consented patient

Exclusion criteria

* total occlusion and collateral flow to target vessel * AV conduction abnormality * Left ventricular hypertrophy * significant valvular heart or primary myocardial disease

Design outcomes

Primary

Measure	Time frame	Description
fractional flow reserve	1day	fractional flow reserve of stenotic coronary artery
target vessel failure	10 year	composite of cardiovascular death, target vessel myocardial infarction, target vessel revascularization

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 9, 2026