Stroke
Conditions
Keywords
Stroke, Exercise, Rehabilitation, Risk factors
Brief summary
Little is known about how exercise can affect heart function in stroke survivors. This study will look at changes in cardiovascular fitness and function after 6 months of exercise. Volunteers will be tested before and after the program and again 2 months later to measure the effects on stroke risk factors, fitness level and flexibility of the arteries. Blood tests will measure cholesterol levels and other signs of inflammation. This study will help us better understand how exercise after stroke can improve heart function and heart health, and ultimately help in lowering future stroke risk.
Detailed description
Purpose To determine the effects of aerobic exercise after stroke on cardiorespiratory fitness, cardiovascular function, stroke risk factors, walking and health-related quality of life. This study will also examine the retention of these effects after the exercise program ends. Methods A randomized controlled study design will be used. Sixty participants will be randomized to participate in one of 2 treatment arms (6 months duration, 3 days / week, 1 hour / session): 1. BALANCE AND FLEXIBILITY (non-aerobic) PROGRAM will be comprised of individualized upper and lower body stretching, or balance activities, yoga- or Tai Chi-style classes. 2. AEROBIC PROGRAM will be comprised of a structured, progressive aerobic training program. Participants will be evaluated at 3 time points - baseline (0 months), post-intervention (6 months) and follow up (8 months) - for stroke risk factors, cardiorespiratory fitness, arterial stiffness, echocardiography measures, inflammatory biomarkers, ambulatory capacity and health-related quality of life.
Interventions
BEHAVIORALAerobic Exercise Program
The AEROBIC PROGRAM will be the Experimental arm of this trial. It will be a structured, progressive aerobic training program that will be 6 months in duration. Classes will be held 3 times / week, for 1 hour / session.
BEHAVIORALNon-aerobic Exercise Program
The BALANCE AND FLEXIBILITY (non-aerobic) PROGRAM will be the Active Comparator arm of this trial. It will be comprised of upper and lower body stretching, or balance activities, yoga- or Tai Chi-style classes. This program will be 6 months in duration. Classes will be held 3 times / week, for 1 hour / session.
Sponsors
University of British Columbia
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
50 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Age 50-80 years old * Has experienced a stroke * At least 12 months post-stroke * Able to stand independently * Able to walk at least 5 metres (assisted devices and guarded supervision is permitted)
Exclusion criteria
* Stroke of non-cardiogenic origin (aneurysm, tumour) * Actively engaged in other stroke rehabilitation services * Class C or D American Heart Association Risk Criteria (uncontrolled arrhythmias) * Resting blood pressure \> 160/100 mmHg * Significant musculoskeletal problems (rheumatoid arthritis) or other neurological conditions (e.g. Parkinson's) * Has a pacemaker * Pain or other co-morbidities (e.g. unclipped aneurysms, uncontrolled seizures etc.) which would preclude participation * Behavioural issues that would limit participation in exercise
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stroke risk factors (blood pressure, heart rate, lipid profiles, glucose metabolism), cardiorespiratory fitness | assessed at baseline (0 months), post-program (6 months) and follow up (8 months) |
Secondary
| Measure | Time frame |
|---|---|
| Arterial stiffness and inflammatory biomarkers | assessed at 0, 6 and 8 months |
| Echocardiography measures | assessed at 0 and 6 months |
| Ambulatory capacity and health related quality of life | assessed at 0, 6 and 8 months |
Countries
Canada
Outcome results
None listed