Breast Cancer, Hodgkin Disease
Conditions
Keywords
Hodgkin disease, Breast cancer
Brief summary
After treatment for Hodgkin disease, secondary cancer, in particular breast cancer induced by treatment, are the first cause of death. The investigators will estimate the risk to develop breast cancer in this population of women treated for hodgkin disease, and will propose women at high rish to participate in an intensive screening program based on an annual detection based on mammography, echography, and RMI.
Interventions
PROCEDUREintensive screening
Each year, women will have breast cancer detection based on mammography, echography and RMI. Questionaries will also be completed.
Sponsors
Institut Paoli-Calmettes
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* women \> 18 years * treated for Hodgkin disease * signed informed consent * high risk of breast cancer
Exclusion criteria
* patients unable to have a regular follow-up
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| efficacy of the screening | 15 years | The efficacy of the screening will be evaluated by the rate of early stage breast cancer detected. The rate of in situ, \< 10 mm(T1b), and N0 will be estimated. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| interest | 1 month | The rate of interest is the % of women at high risk who will accept the intensive screening |
| adhesion | 1 month | The adhesion rate is the % of women who will effectively undergo the first screnning among the women who had accepted their participation in this intensive screening |
| compliance | 15 years | The compliance will be evaluated yearly. The number of exam realised compared to the theoric number and the time between 2 exams will be estimated. |
| psychologic impact | 15 years | The psychologic impact will be assessed yearly by questionnaries evaluating quality of life, anxiety and satisfaction. |
Countries
France
Outcome results
None listed