Healthy
Conditions
Brief summary
The objectives of the proposed study are to assess the effect of walnut consumption on parameters of lipid metabolism, glucose metabolism, incretins and adipokines, endothelial function and blood pressure in healthy men and healthy postmenopausal women
Interventions
DIETARY_SUPPLEMENTwalnut
walnut consumption 48 g/d
Sponsors
Ludwig-Maximilians - University of Munich
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* Postmenopausal healthy women and healthy men * Age \> 50 yrs
Exclusion criteria
* Evidence of alcohol, tabacco or drug abuse * Obesity ≥ 35 kg/m2 * Diabetes mellitus * Hypertension * LDL-cholesterol \> 190 mg/dl, Triglycerides \> 350 mg/dl * History of atherosclerotic disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fasting non-HDL-cholesterol | 8 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| area under the triglyceride curve (AUC-TG) | 8 weeks | area under the plasma triglyceride concentration curve following a standardized oral fat challenge |
| incremental area under the triglyceride curve (iAUC-TG) | 8 weeks | incremental area under the plasma triglyceride concentration curve following a standardized oral fat challenge |
| LDL-cholesterol | 8 weeks | fasting plasma LDL-cholesterol concentration |
| HDL-cholesterol | 8 weeks | fasting plasma HDL-cholesterol concentration |
| triglyceride | 8 weeks | fasting plasma triglyceride concentration |
| glucose | 8 weeks | fasting plasma glucose concentration |
| HOMA | 8 weeks | — |
| insulin | 8 weeks | — |
| HbA1c | 8 weeks | — |
| area under the glucose curve (AUC-glucose) | 8 weeks | area under the plasma glucose concentration curve following a standardized oral challenge |
| area under the insulin curve (AUC-insulin) | 8 weeks | area under the plasma insulin concentration curve following a standardized oral challenge |
| endothelial function | 8 weeks | Postprandial (mixed meal challenge) endothelial function (flow mediated dilatation, flow-independent dilatation) |
Countries
Germany
Outcome results
None listed