Healthy, Obesity
Conditions
Keywords
childhood obesity, adipocytokines, physical exercise, nutrition education
Brief summary
Obesity is now becoming significantly prevalent of an environment characterized by easily available calorics foods combined with sedentary lifestyles. Moreover, it has been demonstrated that obesity is associated with metabolic complications such as disturbed adipocytokines, hormones secreted by adipose tissue. Given these observations, the purpose of this study is to assess the effects of a lifestyle intervention focused on various physical activities and nutrition education on adipocytokines hormones, in severely obese teenagers.
Interventions
BEHAVIORALobesity lifestyle intervention
physical activity 5 times per week + nutrition education
Sponsors
Centre Hospitalier Universitaire de Besancon
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
12 Years to 17 Years
Healthy volunteers
Yes
Inclusion criteria
* to be aged from 12 to 17 * to have a body mass index \> 97 percentile for age and gender
Exclusion criteria
* systemic disease * endocrine disorder * syndromic obesity * subjects receiving medication with a history of recent intercurrent illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adipocytokines (leptin, adiponectin, ghrelin, PAI-1, resistin), based on subject's arterialized capillary blood samples. | during a lifestyle intervention of 9 months |
Secondary
| Measure | Time frame |
|---|---|
| Body weight, body mass index, waist and hip circumference | during a lifestyle intervention of 9 months |
| Body composition, calculated by a multifrequency bioelectric impedance | during a lifestyle intervention of 9 months |
| Glycemia and lipids profile, based on subject's arterialized capillary blood samples analysis. | during a lifestyle intervention of 9 months |
| Insulin resistance, calculated according to the formula of homeostasis model assessment | during a lifestyle intervention of 9 months |
| Systolic and diastolic blood pressure, measured in millimeters of mercury at the level of the left brachial artery, using an automatic blood pressure monitor. | during a lifestyle intervention of 9 months |
Countries
France
Outcome results
None listed