Resistant Starch and Satiety

Satiety Response of Resistant Starches

Status

Completed

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01187875

Enrollment

Registered

2010-08-24

Start date

2009-09-30

Completion date

2011-06-30

Last updated

2012-03-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Adults

Keywords

satiety, dietary fiber

Brief summary

Dietary fiber consumption may contribute to weight regulation by improving satiety. In an earlier study the investigators found that a muffin containing resistant starch was more effective than other fibers in altering satiety. The objective of this study is to determine if 2 resistant starches consumed in muffins alter satiety and whether a mixture of resistant starches is more effective than either alone in enhancing satiety.

Interventions

DIETARY_SUPPLEMENTPlacebo- Fiber free control

Dextrin control administered in a muffin treatment.

DIETARY_SUPPLEMENTHi-maize resistant starch 9g

9g Hi-maize resistant starch administered in a muffin treatment.

DIETARY_SUPPLEMENTNovalose 330 resistant starch 9g

9g Novalose 330 resistant starch administered in a muffin treatment.

DIETARY_SUPPLEMENT4.5g Hi-maize resistant starch and 4.5g Novalose 330

4.5g Hi-maize and 4.5g Novalose 330 in a muffin treatment.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 64 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy men and women * Age 18-64 years * Non-smoking * Not taking medication * Non dieting (weight stable in prior 3 months) * BMI 18-27 * English literacy

Exclusion criteria

* Do not regularly consume breakfast * Food allergies to ingredients found in the study products * BMI \<18 or \>27 * Diagnosed cardiovascular disease, renal disease, hepatic disease, or diabetes mellitus * Cancer in previous 5 years * Any gastrointestinal disease or condition * Recent bacterial infection (\< 3months) * Recent or concurrent participation in an intervention research study * History of drug or alcohol abuse in prior 6 months * Use of lipid lowering, anti-hypertensive, or anti-inflammatory steroid medication * Eating disorder * Vegetarians * People who eat more than approximately 15 grams of fiber per day * Women who are pregnant or lactating * Women with irregular menstrual cycles

Design outcomes

Primary

Measure	Time frame	Description
Satiety response using visual analogue scales	0 minutes postprandially	Satiety response was measured using subjective perceptions of hunger, fullness, satisfaction, and prospective food intake evaluated by previously validated visual analogue scales (VAS).
Satiety response using VAS	15 minutes postprandially	Satiety response was measured using subjective perceptions of hunger, fullness, satisfaction, and prospective food intake evaluated by previously validated visual analogue scales (VAS).

Secondary

Measure	Time frame	Description
Ad libitum food intake	240 minutes postprandially and over 24 hours	—
Breath hydrogen response	0, 240 minutes	—
Gastrointestinal tolerance using visual analogue scales (VAS)	24 hours	Subjective ratings of bloating, stool consistency, and flatulence on VAS. A stool count was also recorded.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026