Stroke
Conditions
Keywords
Stroke
Brief summary
Neuro-psychological, cognitive and biochemical assessment matched with MR-Imaging in acute and chronic poststroke conditions.
Detailed description
The study design relates to affective symptomatology, particularly poststroke depression and posttraumatic stress symptoms as well as to cognitive decline due to stress-related hypercortisolemia in the early phase after stroke. Extended MRI studies including a functional connectivity (fc-MRI) paradigm have been incorporated to study on subacute midbrain neurodegeneration as a possible morphological correlate of functional and clinical findings.
Interventions
None listed
Sponsors
German Federal Ministry of Education and Research
Charite University, Berlin, Germany
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Stroke in MCA/AchA territory of striato-capsular (at least 125mm³) or non-striatal (10-100cm³) involvement * MR-imaging can be conducted 24-48 hours of onset * preserved communication skills
Exclusion criteria
* Patients with psychiatric conditions or medication in the last 4 weeks * severe medical conditions * limited prognosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| occurence of depression (GDS, SKID) | 90 days | Geriatric Depression Scale, Structured Clinical interview for DSM-IV |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change in saliva cortisol | 90days | measurement of saliva cortisol levels |
| change in serumcholine | 90days | measurement of serumcholine |
Countries
Germany
Outcome results
None listed