Absorption
Conditions
Keywords
Vitamin E, Absorption
Brief summary
Despite the emerging interest in tocotrienols, the absorption of tocotrienols in humans remains unclear especially with different fat diets.This study aimed at evaluating the absorption and distribution of tocotrienols in plasma and lipoproteins in associations with high and low fat diets. Different fat level will affect the absorption and distribution of tocotrienols
Detailed description
There is a possibility that the absorption and distribution of tocotrienols may occur differently compared with tocopherols, especially under different fat status
Interventions
DIETARY_SUPPLEMENTTocotrienol
500 mg of tocotrienol will be administered after consumption of high fat diet
Sponsors
University of Malaya
Malaysia Palm Oil Board
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
MALE
Age
22 Years to 25 Years
Healthy volunteers
Yes
Inclusion criteria
* male aged 22-25 * body mass index 18.5 \< X \< 30 kg/m2 * plasma cholesterol \< 5.2 mmol/L, * TAG \< 1.7 mmol/L
Exclusion criteria
* history of cardiovascular disease * diabetic * body mass index \< 18.5 or \> 30 kg/m2 * plasma cholesterol \> 5.2 mmol/L, * TAG \> 1.7 mmol/L * hypertension * currently taking Vitamin E supplement * current use of medication * smoking.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in absorption and distribution of Tocoterienols during high fat and low fat meal by measuring the plasma, chylomicron, and HDL level of tocotrienol | 0, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 24 hours after tocotrienol administration and in take of designated meal |
Countries
Malaysia
Outcome results
None listed