Intermittent Preventive Treatment, Placental Malaria
Conditions
Keywords
Malaria, Pregnancy
Brief summary
The effectiveness of sulfadoxine-pyrimethamine (SP) as intermittent preventive treatment in pregnancy in malaria-endemic areas the effectiveness and efficacy of SP may be compromised by increased SP resistance. This study will evaluate the efficacy of SP by giving SP to asymptomatic parasitemic pregnant women and following them to determine the rates of parasite clearance.
Interventions
DRUGSulfadoxine-pyrimethamine
Sulfadoxine-pyrimethamine tablets, once
Sponsors
Centers for Disease Control and Prevention
Uganda Malaria Surveillance Project
University of California, San Francisco
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* 16-26 weeks gestation based on LMP or ultrasound or fundal height * Axillary temperature \<37.5 degrees C * Informed consent * HIV status known and negative * Blood smear positive for falciparum malaria
Exclusion criteria
* History of hypersensitivity reaction to SP or components of SP * Axillary temperature ≥37.5 degrees C * History of receipt of antimalarials or antibiotics with antimalarial activity\* in the past month * Residence \> 30 km from the ANC clinic or unwillingness to return for follow-up visits * Hemoglobin level \< 5 gm/dL * These medications include all antimalarials, rifampin, doxycycline, clindamycin, tetracycline, erythromycin, azithromycin, chloramphenicol.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Parasite clearance | 42 days | Clearance of parasites in pregnant women with asymptomatic parasitemia after administration of SP |
Countries
Uganda
Outcome results
None listed