Long-term Outcome of General Anesthesia on Dysgnosia

Long-term Outcome Followed-up of the Cognitive Disorders After General Anesthesia

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01184638

Acronym

LOGAND

Enrollment

10000

Registered

2010-08-19

Start date

2010-08-31

Completion date

2020-08-31

Last updated

2014-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Amnestic,, Cognitive Disorders, Delirium,, Dementia,

Keywords

Cognitive Disorders, General anesthesia, Sevoflurane, Propofol, Memory

Brief summary

Cognitive disorders in patients underwent general anesthesia are discussed for decades, but whether there were precise relationship between general anesthesia and dysgnosia is yet to be guaranteed. Although controversial data reported from experimental studies in animals, the investigators still proposed that general anesthetics could impair the normally organized system of the central nervous system, which finally displayed a dysfunction of cognition after general anesthesia in a short- or long-term period. Therefore, different types of general anesthetics such as inhalational anesthetics and intravenous anesthetics, the investigators hypothesized, had a long-term influence on patients' cognitive ability.

Interventions

DRUGSevoflurane

1-8% sevoflurane for maintaining the whole period of general anesthesia

DRUGPropofol

1-4 mg/kg/h of propofol during the whole period of general anesthesia

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

10 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Patients with informed consents * Without basal disorders of neurology and psychiatrics

Exclusion criteria

* With the history of cognitive disorders * With chronic neurological disorders * Cannot communicate with investigators * Cannot stand general anesthesia

Design outcomes

Primary

Measure	Time frame	Description
Cognitive ability	The 10th year since postoperation	Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory

Secondary

Measure	Time frame	Description
Cognitive ability	One hour before operation	Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory

Countries

China

Contacts

Primary ContactFuZhou Wang, PhD MD

zfwang50@gmail.com86 25 84460777

Backup ContactXiaoFeng Shen, MPH, MD

sxf0418@njmu.edu.cn86 25 84460777

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026