Myositis
Conditions
Keywords
Myositis, Physical exercise, Disability
Brief summary
The objectives of this study are to test if hypoxia in muscle tissue is an important factor contributing to clinical symptoms in chronic rheumatic muscle inflammation and to evaluate if a 12 week endurance exercise program will improve muscle tissue hypoxia and disability in patients with chronic rheumatic muscle inflammation.
Interventions
OTHERPhysical Exercise
12 weeks of physical exercise.
Sponsors
Uppsala University Hospital
Sahlgrenska University Hospital
Karolinska Institutet
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients with chronic, stable polymyositis or dermatomyositis with diagnosis of definite or probable polymyositis or dermatomyositis (Bohan and Peter 1975) * Age 18-80 years * Duration since diagnosis \> 6 months * Exercising \< once a week, * Stable disease activity and medication for at least one month. Ten healthy controls matched for age, gender and physical exercise level will be included. \-
Exclusion criteria
* Severe pulmonary fibrosis * Heart or lung conditions that contraindicate vigorous exercise * Severe osteoporosis * Not being able to perform the exercise program.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hypoxia related metabolites. | At baseline before intervention. |
Secondary
| Measure | Time frame |
|---|---|
| Muscle impairment. | At baseline before intervention. |
Countries
Sweden
Contacts
Primary ContactIngrid E Lundberg, MD, PhD, Prof
Outcome results
None listed