Corneal Biomechanics With Hydration in Normal and LASIK Eyes

Analysis of Corneal Biomechanics Based Upon Central and Peripheral Corneal Thickness in Normal and Post Refractive Surgery Eyes

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01183702

Enrollment

Registered

2010-08-18

Start date

2004-02-29

Completion date

2012-12-31

Last updated

2017-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laser Corneal Surgery

Keywords

LASIK vs. non-LASIK

Brief summary

The research will utilize LASIK and non-LASIK populations to analyze the biomechanical differences between these corneas.

Detailed description

The research will utilize LASIK and non-LASIK populations to analyze the biomechanical differences between these corneas. Subjects' corneas will be swelled with warmed, humidified nitrogen using modified diving goggles to assess structural changes due to a two hour swelling period. Subjects will be examined prior to swelling by a registered ophthalmologist to ensure that the cornea is healthy enough to undergo the swelling procedure. Pre-swelling and post-swelling data will be compared for parameters such as elasticity, density, thickness, axial and tangential curvature, hydration, and intraocular pressure in the central, paracentral, and peripheral regions. Analysis of pre-swelling and post-swelling data will allow for a better understanding of the structural changes created by LASIK. In addition, this project will allow for a better understanding of how common fluctuations in hydration levels affect normal corneal parameters as given by common devices in both populations to allow for corrections for more accurate measurements.

Interventions

PROCEDURELASIK surgery

Participants have received LASIK surgery and their eyes are healthy.

OTHERNo Intervention

Participant has healthy eyes not altered by LASIK surgery.

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy cornea without LASIK surgery as determined by a registered ophthalmologist. * Healthy cornea with LASIK surgery as determined by a registered ophthalmologist.

Exclusion criteria

* Children under 18. * Unhealthy cornea as determined by a registered ophthalmologist.

Design outcomes

Primary

Measure	Time frame
Corneal hydration (swelling)	Two hours

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026