Mitochondrial Dysfunction and Oxidative Stress in Chronic Obstructive Pulmonary Disease (COPD) Patients

Mitochondrial Respiratory Chain and Peripheral Muscle Dysfunction in COPD Patients

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01183052

Enrollment

Registered

2010-08-17

Start date

2009-06-30

Completion date

2010-12-31

Last updated

2012-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD Patients

Keywords

COPD, exercise tolerance, oxidative stress

Brief summary

The purpose of this study is to understand the underlying mechanisms of improved exercise tolerance in COPD patients after training program.

Detailed description

Training protocol used is based on recommendations (Nici et al., 2006) and was previously used in our group (Varray et al., 1991; Vallet et al., 1997). A minimum of 20 sessions in 4-6 weeks were proposed. The exercise intensity of exercise corresponds to target heart rate at ventilatory threshold measured during incremental exercise test. Training at this intensity allowed us to individualize effort for each patient.

Interventions

OTHERTraining

20 sessions of training

Study design

Allocation

Intervention model

SINGLE_GROUP

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

50 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Sedentary mild to severe COPD patients

Exclusion criteria

* Neuromuscular disease * Chronic heart failure * Renal diseases * Liver diseases * Obesity

Design outcomes

Primary

Measure	Time frame
Cellular effects of exercise training at the ventilatory threshold intensity	6 to 8 weeks

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 1, 2026