Lung Cancer, Non-Small Cell Lung Cancer, Small Cell Lung Cancer
Conditions
Keywords
Lung Cancer Non-Small Cell Cancer (NSCLC), Lung Cancer Small Cell Lung Cancer (SCLC)
Brief summary
Patients treated with radiation therapy for lung tumors can experience inflammation after treatment. This study hopes to evaluate the use of breath analysis to evaluate changes in the composition of exhaled breath in patients undergoing radiotherapy. If changes can be detected, this may ultimately serve as biomarkers for identifying patients at highest risk for radiation-induced lung injury (radiation pneumonitis).
Interventions
PROCEDUREExhaled Breath Sampling
Standard of care
Sponsors
Stanford University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diagnosis of any type of lung tumor * Medical recommendation (independent of the study) that the patient undergo thoracic radiation therapy. Radiation therapy may be either fractionated or hypofractionated (i.e. radiosurgery) * Age \>= 18 years old * Any gender and any ethnic background will be recruited * Capable of giving written informed consent
Exclusion criteria
* Inability of giving written informed consent * Pregnancy or breast-feeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pre and post-radiation FeNO (fraction of exhaled nitric oxide) measurements | Every 3 months for 1 year |
Secondary
| Measure | Time frame |
|---|---|
| Pre and post-radiation CO (carbon monoxide), CO2 (carbon dioxide), and N2O (nitrous oxide) measurements and feasibility as the fraction of patients unable to give a breath sample. Adverse events are not expected but any that appear related to the breath | 1 yr |
Countries
United States
Outcome results
None listed