Anxiety Disorders, Depression
Conditions
Brief summary
The overall aim of this study is to develop and test a tailored Internet-delivered psychological treatment for patients with mild to moderate major depression and comorbid anxiety symptoms and compare its efficacy to a non-tailored treatment and to an active control group.
Detailed description
Internet-delivered cognitive behaviour therapy (CBT) has emerged as a promising way to administer evidence-based psychological treatments. Mild to moderate major depression has previously been found to treatable via the Internet, with the provision that minimal therapist guidance is given. However, previous research has not taken the issue of comorbidity into account. It is well known that major depression often is accompanied by anxiety and in addition the symptom profile in major depression may differ substantially. The idea behind the proposed research is to tailor the Internet intervention according to the symptom profile. By used a large set of treatment modules (text-based) we aim to diagnose and then prescribe modules. In a randomized trial we want to compare this procedure (e.g., tailored CBT) with the standard Internet-delivered CBT. We will also include a control group in the form of a supervised online discussion group who will later receive CBT.
Interventions
BEHAVIORALTailored Internet-delivered CBT
This intervention contains 8-10 text-based self-help modules in which 4 modules are fixed (the first three and the last) and the rest are prescribed following the diagnostic telephone interview. These modules contain material on panic disorder, social phobia, stress management, assertiveness training, concentration, relaxation among other things.
BEHAVIORALNon-tailored Internet-delivered CBT
Specific text-based self-help for depression, which has previously been tested in three previous randomized trials. Anxiety symptoms will not be covered, but insomnia is included as a module together with advice on health.
BEHAVIORALOnline discussion group
Participants take part of an online discussion group which are monitored daily. New discussion topics on depression are introduced every week.
Sponsors
Linkoeping University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Clinical diagnosis of Major Depressive Disorder * 15 or more on MADRS-S
Exclusion criteria
* Severe depression (more than 35 on MADRS-S or based on interview) * Severe psychiatric condition (e.g. psychosis or bipolar disorder) * Changed medication during the last three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Beck Depression Inventory (BDI) | One week before the treatment starts |
Secondary
| Measure | Time frame |
|---|---|
| Beck Anxiety Inventory (BAI) | One week before the treatment starts |
| Montgomery Åsberg Depression Rating Scale Self-report (MADRS-S) | One week before the treatment starts |
| Quality of Life Inventory (QOLI) | One week before the treatment starts |
Countries
Sweden
Outcome results
None listed