Tissue Doppler Imaging (TDI) Versus Electrocardiography (ECG) Interventricular Pacing Delay Optimization in Cardiac Resynchronization Therapy (CRT)

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01179997

Enrollment

156

Registered

2010-08-11

Start date

Unknown

Completion date

Unknown

Last updated

2014-02-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Resynchronization Therapy, Heart Failure

Brief summary

The aim of this study was to compare the response to cardiac resynchronization therapy when the interventricular pacing interval was optimized by Tissue Doppler Imaging (TDI) to response when it was optimized following QRS width criteria.

Interventions

DEVICEInterventricular pacing delay optimization by using Tissue Doppler-derived displacement curves

DEVICEElectrocardiographic optimization of the interventricular pacing delay according to QRS width

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Patients submitted to de novo implant due to conventional cardiac resynchronization therapy indications.

Exclusion criteria

Design outcomes

Primary

Measure	Time frame	Description
6-month echocardiographic response	—	Reduction of the end-systolic volume (measured in mililiters according to transthoracic echocardiography) of \>10% as compared to the baseline value.

Secondary

Measure	Time frame	Description
6-month clinical response	—	Combined end-point consisting in no death due to cardiovascular reasons, no heart transplantation and distance increase of \>10% (measured in meters) in the 6-minute walking test.

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026