Lifestyle Modifications and the Progression of Chronic Kidney Disease

Effect of Lifestyle Interventions on the Progression of Kidney Disease in Patients With Chronic Kidney Disease

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01179906

Enrollment

Registered

2010-08-11

Start date

2006-01-31

Completion date

2009-02-28

Last updated

2010-08-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients With Stage 2-4 Chronic Kidney Disease

Keywords

CKD

Brief summary

Aerobic training has been shown to favorably alter several of the known risk factors for coronary artery disease including hypertension, dyslipidemia, obesity, and diabetes (1). It seems logical that if these risk factors were aggressively controlled in patients with chronic kidney disease (CKD) by implementing lifestyle changes (e.g., diet and exercise training) to support the pharmacologic interventions that are necessary for the control of the disease, then the rate of progression of the disease may be altered. However, to date, there is no clear research evidence to support this hypothesis. Therefore the aims of the proposed study are: 1. To test the hypothesis that lifestyle interventions (i.e., dietary modification and regular, long-term aerobic exercise training) will favorably alter the natural progression of CKD in a sample of patients compared to a control group who will receive the current standard care. 2. To explore possible mechanisms that could contribute to the observed changes.

Interventions

BEHAVIORALExercise training

Subjects exercise trained for 48 weeks with personal trainers at a college wellness center

BEHAVIORALDiet modification

Exercise training using personal trainers 3 times per week. Individuals were trained at a moderate intensity

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Stages 2-4 CKD

Exclusion criteria

* CAD * MI

Design outcomes

Primary

Measure	Time frame	Description
Glomerular filtration rate (GFR)	48 weeks	GFR was estimated using the MDRD equation, creatinine clearance, urea clearance

Secondary

Measure	Time frame	Description
24 hour urine protein output	48 weeks	urine protein output is measured before and after 48 weeks of the training program

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026