Type 2 Diabetes
Conditions
Brief summary
The purpose of this study is to investigate the prevalence of cardiac disease/coronary artery disease and diagnostic yield of different non-invasive methods in patients with type 2 diabetes 40-75 years of age at examination. Exercise tests, Doppler echocardiographic examination with Tissue Velocity Imaging, stress Echocardiography, transthoracic Doppler of coronary arteries with coronary flow reserve, and cardiac MRI with late enhancement at rest, and perfusion after vasodilatation stress will be used in the study. A subpopulation will in addition measure forearm vasodilation(FMD) and CFR before and after 4 months of exercise training.
Interventions
OTHERDiagnostic
Diagnostic non-invasive tests:Dopplerechocardiography, cardiac MRI
Sponsors
Volda Hospital
Norwegian University of Science and Technology
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
40 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Type 2 diabetes * Age at diagnosis \> 30 years * Age at inclusion 40-75 years
Exclusion criteria
* Angina pectoris * Coronary angiography/stress-test diagnostic of coronary artery disease last 3 years * Previous myocardial infarction, coronary bypass operation/PCI or heart failure * Clinical indication for stress -testing * Active bronchospasm excluding use of adenosine * eGFR \< 30 ml/min/m2 * short estimated life expectancy due to cancer, chronic liver/renal diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of cardiac abnormalities/disease according to different examination modalities | at primary examination |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Feasibility of transthoracic coronary Doppler examination/Coronary Flow Reserve, and diagnostic yield related to MRI. | at baseline | Descriptive study; that is at baseline examination except substudy training group which will also be examined after 4 months of exercise training |
| Relationship between CFR in LAD and forearm FMD | 4 months | Relationship between CFR in LAD and forearm FMD before and after 4 months of exercise training in diabetics. Substudy |
| Doppler echocardiographic findings related to clinical, laboratory and MRI findings | at baseline | Special emphasis on new modalities as strain/strain rate at rest and stress. At baseline examination (no follow up) |
| Feasibility of transthoracic coronary Doppler examination/Coronary Flow Reserve, and diagnostic yield related to MRI | 4 months | in exercise training group |
Countries
Norway
Outcome results
None listed