Laboratory Outcome Predictors in Coronary Surgery

Markers of Tissue Perfusion as Predictors of Complicated Evolution in Patients With Left Ventricular Dysfunction Submitted to Coronary Artery Bypass Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01178866

Enrollment

Registered

2010-08-10

Start date

2006-01-31

Completion date

2008-03-31

Last updated

2010-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Bypass Surgery, Left Ventricular Dysfunction, Tissue Hypoperfusion

Keywords

thoracic surgery, myocardial revascularization, left ventricular dysfunction, tissue perfusion, prognosis

Brief summary

Evaluate less employed markers of tissue hypoperfusion as venoarterial carbon dioxide partial pressure difference (ΔPCO2) and estimated respiratory quotient (eRQ) combined to other classically studied markers as predictive factors of complicated clinical course after cardiac surgery in patients with left ventricular dysfunction.

Detailed description

Patients with left ventricular dysfunction are more susceptible to tissue hypoperfusion and presents more frequently both low cardiac output syndrome and systemic inflammatory response, what results in prolonged stay in intensive care unit (ICU), and higher mortality rates when compared to patients with normal ventricular function. The early prediction of prolonged ICU stay through the detection of tissue hypoperfusion may improve the management of care and decrease morbidity of this particular group of patients. However, classic markers of tissue hypoxia as central venous saturation, base excess, lactate may not be predictors of outcome in cardiac surgery patients with left ventricular dysfunction. The question addressed in this study is if less employed markers of tissue hypoperfusion as as venoarterial carbon dioxide partial pressure difference (ΔPCO2) and estimated respiratory quotient (eRQ) have predictive value of prolonged ICU stay in patients with left ventricular dysfunction submitted to coronary artery bypass surgery.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* adults * left ventricular dysfunction (ejection fraction \< 50%) * patients undergoing coronary artery bypass surgery requiring the use of Cardiopulmonary Bypass (CPB)

Exclusion criteria

* renal failure (creatinine clearance lower than 40 ml/min/m2), * hepatic dysfunction * endocrinologic disorders * pulmonary disease * uncontrolled diabetes mellitus * a history of fever or infection within the week before surgery * previous anemia (hemoglobin ≤ 10.0 g/dL)

Design outcomes

Primary

Measure	Time frame	Description
Complicated clinical course after coronary artery bypass surgery	within the first 30 days after surgery	Complicated clinical course defined as death within the first 30 days after surgery or ICU stay more than 4 days.

Countries

Brazil

Outcome results