The Effects of Three Oral Medications on Post-operative Pain Following Endodontic Treatment

Status

Completed

Phases

Phase 1Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01178203

Enrollment

Unknown

Registered

2010-08-10

Start date

2010-07-31

Completion date

2010-08-31

Last updated

2010-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain Management, Pulpitis

Keywords

Endodontics, pain, visual analogue scale, NSAIDs

Brief summary

Aim: eliminating or reducing pain following endodontic treatment is of great importance. The aim of this study is to compare the effects of Tramadol, Novafen and Naproxen on post-operative pain following instrumentation of root canals in teeth with irreversible pulpitis. Sample size: one hundred patients considering the inclusion and exclusion criteria were selected. Intervention and outcome: The effect of Tramadol, Novafen and Naproxen on post-operative pain following instrumentation of root canals in teeth with irreversible pulpitis was evaluated.

Interventions

DRUGPlacebo

Placebo

DRUGTramadol

Tab, 100mg in 6, 12 and 24 hours after root canal treatment

DRUGNovafen

325 mg in 6, 12 and 24 hours after root canal treatment

DRUGNaproxen

Tab, 500 mg in 6, 12, and 24 hours after root canal treatment

Study design

Intervention model

PARALLEL

Primary purpose

TREATMENT

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Inclusion criteria

1. The subjects were 20-60 years of age with no systemic diseases and females were not pregnant; 2. No history of taking any analgesics or other drugs prior to presenting for treatment; 3. Patients had moderate to severe pain associated with irreversible pulpitis in single-rooted premolars or anterior teeth.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026