The Erlangen Fitness and Prevention Study (EFOPS).

Effects of Exercise on Fracture Risk, Bone Mineral Density and Falls in Postmenopausal Women. The Long-term Erlangen Fitness and Prevention Study.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01177761

Acronym

EFOPS

Enrollment

Registered

2010-08-09

Start date

1998-10-31

Completion date

2023-11-30

Last updated

2023-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Early Postmenopause, Osteopenia, Osteoporosis

Keywords

Osteoporosis, exercise, fractures, Bone Mineral Density, CHD-risk

Brief summary

The study determines the long-term effect of exercise on osteoporotic fracture risk. Since actually no controlled supervised exercise study exceeds the time frame of 4 years, knowledge concerning the long-term effect of exercise on fractures and fracture-risk factors is scarce. Within the Erlanger Fitness and Osteoporosis Study (EFOPS, an ongoing controlled exercise study with currently 16 years of supervised exercise with 45-50 osteopenic, early-postmenopausal women in exercise and sedentary control group each, the investigators therefore focus on overall-fractures, Bone Mineral Density and falls.

Interventions

PROCEDUREphysical exercise

Two sessions/week, 50 weeks/year over 12 years of high intensity exercise training

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

48 Years to No maximum

Healthy volunteers

Inclusion criteria

* participants of the EFOPS-study, * 12 years of exercise training according to the EFOPS-protocol (exercise).

Exclusion criteria

* medication and diseases affecting bone metabolism, * inflammable diseases, * cardiovascular diseases, * start of relevant physical exercise programs beside the EFOPS protocol.

Design outcomes

Primary

Measure	Time frame	Description
overall-fractures (low-trauma)	16 year follow-up	As assessed by questionnaire and structured interview
Bone Mineral Density at Lumbar Spine and Proximal Femur	16 year follow-up	As assessed by Dual-Energy X-ray Absorptiometry (DEXA)

Secondary

Measure	Time frame	Description
10-year coronary heart disease (CHD) risk	16 year follow-up	As assessed by Framingham Risk Factor Calculator according to Wilson.
Metabolic Syndrome Z-Score	16 year follow-up	Metabolic Syndrome Z-Score Index according to Johnson

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 23, 2026